split antigen

{{biochemistry}} In the testing of cell surface antigens, an antigen that has a more refined or specific cell surface reaction relative to a broad antigen.(Example: HLA-B51 and HLA-B52 are split antigens of HLA-B5)<ref name>Okimoto K, Juji T, Ishiba S, Maruyama H, Tohyama H, Kosaka K. ''HLA--Bw54 (Bw22-J, J-1) antigen in juvenile onset diabetes mellitus in Japan.'' Tissue Antigens 1978 11(5):418–22 pmid=694905</ref>